Bitcoin (BTC) exchange-traded funds (ETFs) in the U.S. saw outflows of $242.6 million on Tuesday in their worst day since Sept. 3, according to data from SoSoValue.

The outflows snapped an eight-day streak of inflows as BTC lost as much as 6% amid an acute sharpening of tensions in the Middle East that saw Iran fire around 200 ballistic missiles at Israel on Tuesday. The strike followed Israel's attacks on Hezbollah, designated a terror group by more than 60 jurisdictions including the U.S., European Union and Arab League, in Lebanon in recent weeks. Israeli Prime Minister Benjamin Netanyahu vowed to retaliate.

Bitcoin fell to a low of $60,300, erasing almost all of its gains since the U.S. Federal Reserve's interest-rate cut last month, signaling an inauspicious start to "Uptober," the community's affectionate name for the calendar month that has historically seen the highest gains for BTC. The largest cryptocurrency has lost 2.6% since the start of the month, CoinDesk Indices data show.

Ether ETFs also suffered on Tuesday with outflows of $48.5 million, the worst day since Sept. 23.

Read More: Bitcoin Ends Historic September With a Dip, but Breakout May Not Come Before U.S. Election

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