The DeSci track is facing a long winter; can Pump.Science's new compound break through the FUD dilemma?

Author: Biteye

Previously, there was Pump.fun, which earned tens of millions of dollars daily, and now there is Four.Meme, which CZ is promoting. The casino effect of on-chain launch platforms remains hot. On February 8, the long-silent DeSci (Decentralized Science) track welcomed news that the established project Pump.Science is set to launch a new platform next week. Following the announcement, $Rif and $Uro both rebounded by 20%. Earlier,

Pump.Science co-founder Benjels stated in an interview that 20 new compound tokens would be launched by Christmas 2024.

However, in reality, he has delayed this action until now. Within three months, influenced by external factors such as interest rate cuts, the official tokens $Rif and $Uro of Pump.Science have dropped over 95% from their market cap highs of 240m and 140m, respectively. During the same period, the DeSci financial layer project BIO, after launching on Binance, also saw a decline of about 90% from its market cap peak. The DeSci track, which was once highly anticipated and capable of further achieving mass adoption, now seems to be in a dire situation.

Will the new launch platform of Pump.Science spark a resurgence in DeSci?

According to the official documentation from the Pump.Science community, the process for the new launch platform is as follows:

1. Users list a compound along with a token on the Pump.Science platform.
2. Users can buy and sell tokens on a Bonding Curve with parameters identical to those of Pump.fun to support the research of this compound. 79% of the tokens are issued along the Bonding Curve. When the token market cap reaches 303 Sol (with 85 Sol in circulation), the Bonding Curve will close. 82 Sol of liquidity will be migrated to Meteora for trading. 3 Sol will be used to pay for the corresponding worm experiment fees.

It is particularly noteworthy that the new launch platform of Pump.Science will implement a dynamic fee structure to deter sniper bots and prevent automatic loopholes during the initial token sale. Specific measures include:

1. Bot deterrence: The dynamic fee structure is specifically designed to reduce the front-running trades of sniper bots.
2. Early risk: The fees for the first 150 slots (approximately 2 minutes) are extremely high (99.99%), which will significantly reduce the number of tokens received by buyers.
3. Monitoring activity: Between the 150th and 250th slots (2-4 minutes), the fees will drop rapidly.

Dynamic fee structure curve:

The white paper also states that all new compounds need to allocate a certain share for the builders and holders of $Rif and $Uro. Undoubtedly, the launch of a new token launch platform by Pump.Science is a grand "self-rescue" effort. The weak DeSci track urgently needs new attention hotspots and wealth creation effects. Now, hunters on the Sol chain have been lost for too long among the various AI Agents and celebrity coins, and the BSC chain has seen CZ's clear calls diverting attention. In this crisis-ridden on-chain environment, can the DeSci craze like that of Rif and Uro be reignited? With new compounds, new developers, and new attention increments joining, can more DeSci gameplay be activated to attract fresh capital? Three months after the grand announcement of DeSci projects, we have indeed reached a critical juncture that will determine whether DeSci will thrive again or fade into oblivion.

90% of overfunding refunded; the new compound EGS with a $Pain-style presale sparks heated discussion

At 3:19 AM on February 9, the official Twitter of Pump.Science commented on its upcoming compound project $EGS @EGCGxSFN, stating, "Earning trust is the most admirable thing." A look at Twitter reveals that the new compound project $EGS unexpectedly opened a 24-hour presale window on the morning of February 7. According to on-chain data, the presale wallet address for $EGS ultimately raised 1223 Sol before block height 319172095. More notably, the project team announced on Twitter that they would refund 91.87% of the raised funds, retaining only 100 Sol for token launch and liquidity support. This "high refund" strategy during the presale is reminiscent of the previously popular $pain project, but the refund behavior and refund ratio of EGS have set a precedent for DeSci projects. The EGS project team announced on Twitter, "In 24 hours, without marketing, without whales, we proved our trust in science." They also announced that EGS would launch with a market cap of 100k, rewarding the diamond hands of DeSci, with the effective presale payments having already yielded about three times the profit.

EGS stands for the compounds Epigallocatechin Gallate and Sulforaphane. EGCG is the core active ingredient in green tea, known as the "king of antioxidants," which inhibits cellular aging by activating the AMPK pathway and clears free radicals to reduce oxidative damage. Research shows that EGCG can extend the lifespan of model organisms such as nematodes and fruit flies by up to 20%, with mechanisms including the inhibition of pro-inflammatory factors, enhancement of mitochondrial function, and potential epigenetic regulation to delay telomere shortening. Sulforaphane, derived from cruciferous vegetables like broccoli, acts as a "cellular guardian," significantly enhancing cellular antioxidant capacity by activating the Nrf2 pathway. Experiments have confirmed that Sulforaphane can extend the lifespan of mice by about 15%, with key roles including promoting autophagy to clear senescent cells, repairing DNA damage, and inhibiting chronic inflammation associated with aging (such as the NF-κB pathway). Both compounds synergistically delay aging through multiple targets and are among the few natural compounds with clinical translation potential as longevity candidates.

Clearly, the new compound inherits the IP monetization logic of Rif and Uro while reducing risk through high refunds during the presale, which is the "low threshold, high odds" story that DeSci urgently needs. However, can such a topic-rich presale approach, combined with the DeSci narrative of "trusting science," align with Rif and Uro after the new platform launch? The answer is uncertain. Pump.Science co-founder Benjels candidly stated, "The problem with DeSci is that the narrative is grand, but implementation is difficult." "Users want to support science while also hoping for speculative returns; balancing the two is key." In today's market, where price surges are seen as justice, a singular grand narrative of decentralized science has been proven unacceptable to the market. The road to revitalization for the DeSci track remains long and arduous, urgently needing more eye-catching gameplay to capture sensitive attention within the community. One can only hope that this time, the new compounds from Pump.Science can bring new increments to the battered DeSci track and provide both wealth and spiritual comfort to those diamond hands of DeSci who continue to persevere.

Appendix:

Pump.Science

Overview of new compounds

• Punicalagin & Berberine: Pomegranate polyphenols with strong antioxidant and anti-inflammatory effects; Berberine: an AMPK activator that can regulate blood sugar and improve metabolic health. Together, pomegranate polyphenols support cardiovascular health and anti-inflammatory pathways, complementing the metabolic effects of Berberine.

• Resveratrol & Berberine: Resveratrol, a polyphenol that can activate sirtuins, enhance mitochondrial efficiency, and mimic caloric restriction effects; Berberine: an AMPK activator that can regulate blood sugar and improve metabolic health. Together, Resveratrol and Berberine can activate AMPK and sirtuins, potentially leading to longevity, metabolic control, and enhanced cellular repair capabilities.

• Ginsenoside Rh2: Ginsenoside Rh2, a bioactive compound in ginseng, has anti-cancer, neuroprotective, and anti-inflammatory effects.

• Aspalathin & Caffeine: Aspalathin, a bioactive flavonoid compound found in Rooibos tea, has antioxidant and blood sugar-lowering effects; Caffeine, a stimulant, can enhance mental and physical performance. Together, Aspalathin can counteract the potential negative effects of caffeine on blood sugar and stress hormones, providing a more balanced stimulant response.

• Gossypol & Catechin Hydrate: Gossypol, a polyphenol with potential anti-cancer and metabolic effects; Catechin hydrate, a catechin similar to EGCG, has strong antioxidant properties. Together, these two compounds can jointly regulate cellular stress responses and improve metabolic efficiency.

• Biotin & Berberine: Biotin, a substance essential for fatty acid metabolism, glucose regulation, and skin health; Berberine, a metabolic regulator that can enhance insulin sensitivity. Together, Biotin can complement the effects of Berberine by improving lipid metabolism and enhancing mitochondrial function.

• Urolithin A & EGCG: Urolithin A, a metabolite extracted from pomegranate, can promote mitophagy (recycling of damaged mitochondria); EGCG, a green tea catechin, has strong antioxidant and anti-inflammatory effects. Together, EGCG and Urolithin A support mitochondrial function and longevity pathways, potentially enhancing cellular energy efficiency.

• Berberine & Quercetin: Berberine, a metabolic regulator that can enhance insulin sensitivity, lower blood sugar, and support cardiovascular health; Quercetin, a flavonoid with anti-inflammatory, antioxidant, and antiviral properties that promotes nutrient absorption. Together, Quercetin can enhance the bioavailability of Berberine while also complementing its metabolic effects, thereby improving glucose regulation and mitochondrial function.

• Hesperidin & DHM (Dihydromyricetin): Hesperidin, a flavonoid compound found in citrus fruits, can improve blood circulation, reduce oxidative stress, and support vascular health; DHM (Dihydromyricetin), used for liver protection, supporting alcohol metabolism, and neuroprotection. Both compounds can regulate liver enzymes and inflammatory pathways, enhancing detoxification and metabolic recovery capabilities.

• EGCG: Green tea catechin with strong antioxidant and anti-inflammatory effects.

• Caffeine: A stimulant that can enhance energy, cognitive function, and endurance. Liver detoxification reduces premature death.

• Artemisinin: Extracted from sweet wormwood, it has anti-malarial, anti-cancer, and anti-inflammatory effects.

Recently, with Binance Research reaffirming the DeSci track, BIO, Rif, and Uro have all surged by 20%. It seems that the wind of DeSci is about to rise again. Meanwhile, these compounds are also set to launch on the new Pump.Science platform, making it essential for everyone to continuously monitor the quality tokens among the wide array of token launches, selecting projects that are serious and capable of delivering results. DYOR!

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